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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options

Explore this test

Test Code 87108

Test Details

Polygenic Risk Map™- Female Complete

Boston Heart’s Polygenic Risk Map test is a genetic test that leverages Polygenic Risk Score (PRS) analysis and reporting. The resulting risk scores provide clinical insights into a variety of important health conditions.


Illumina Infinium Global Screening Array technology

Patient Preparation


Preferred Specimen


Alternate Specimen

Whole blood

Transport Temperature

Room temperature


6 months at room temperature

Lab Values

Lab Values

Polygenic Risk Map™- Female Complete

Polygenic risk scores included in the Female Complete Panel:

  • Coronary Artery Disease (CAD) – Leading cause of death.
  • Stroke – 5th most common cause of death in the US.
  • Atrial Fibrillation – 5-fold increase in stroke risk.
  • Type 2 Diabetes – 3-fold increase in CAD risk.
  • Hypertension – Causes CAD, stroke, and kidney disease.
  • BMI – Increases risk of CAD, diabetes and some cancers.
  • Triglycerides -Increases risk of CAD and pancreatitis.
  • Low HDL Cholesterol – Increases risk of CAD.
  • High LDL Cholesterol – Increases risk of CAD.
  • Lipoprotein (a) – Increases risk of CAD and aortic stenosis.
  • Alzheimer`s Disease – The leading cause of dementia.
  • Inflammatory Bowel Disease (IBD) – Ulcerative colitis and Crohn’s disease risk.
  • Breast Cancer – A leading cause of cancer in women.
  • Ovarian Cancer – Hormone driven cancer in women.
  • Brain Cancer – Difficult cancer to diagnose.
  • Pancreatic Cancer – Difficult cancer to diagnose in early stages.
  • Kidney Cancer – Cancer that responds well to early intervention.
  • Melanoma – Early screening for those at high risk.
  • Osteoporosis – A common cause of bone fractures.
  • Early Menopause – Risk of menopause before age 45.
  • Psoriasis – Auto-Immune skin disorder.
  • Celiac Disease – Auto-Immune gastrointestinal disorder.
  • Ancestry – Based on 26 global populations.
Test Details
Clinical Significance

Clinical Significance

Polygenic Risk Map™- Female Complete

  • Risk scores are determined by numerous well-studied genetic variations, and allow for impactful and targeted application of genomic testing to personalized medicine.
  • High-risk individuals generally have a substantially increased relative genetic risk for these conditions as compared to low-risk subjects.
  • Because lifetime risk of these conditions are also substantially influenced by environment, lifestyle, and medical care, a greater understanding of genetic risks may lead to greater preventive efforts.
  • Cost effectiveness studies suggest that providers can reduce cardiovascular events and healthcare system costs by using polygenic risk scores in appropriate patients.1
  • This type of testing is meant to augment rather than replace standard risk factor assessments for cardiovascular disease, breast cancer, prostate cancer or other conditions.


  1. Mujwara D, Henno G, Vernon ST, et al. Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk-Enhancing Factor in the Pooled Cohort Equation: A Cost-Effectiveness Analysis Study. J Am Heart Assoc. 2022;11(12):e025236
Lab Values
Treatment Options

Treatment Options

Polygenic Risk Map™- Female Complete

Genome-guided prevention by personalization of:

  • Dietary choices
  • Physical activity
  • Environmental factors
  • Medical care and screening
  • Medication
Clinical Significance