Explore this test

  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Explore this test

Test Code 410

Test Details

C-Peptide

Connecting Peptide (C-peptide) is a polypeptide produced by β-cells of the pancreas along with insulin. It serves as an accurate measure of insulin production, even in patients receiving insulin treatment.

Methodology

Electrochemiluminescence immunoassay

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)

Alternate Specimen

1.0 mL (minimum) plasma collected in EDTA plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated:  3 days

Lab Values

Lab Values

C-Peptide

  • Low:  < 1.40 ng/mL
  • Optimal:  1.40 – 3.30 ng/mL
  • High:  > 3.30 ng/mL
Test Details
Clinical Significance

Clinical Significance

C-Peptide

Elevated C-peptide levels associated with:

  • hyperinsulinemia
  • insulin resistance
  • obesity
  • renal insufficiency

 

Decreased C-peptide levels associated with:

  • insulin deficiency
  • starvation
  • hypoglycemia
  • Addison’s disease
  • post pancreatectomy
  • High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.
Lab Values
Treatment Options

Treatment Options

C-Peptide

  • Insulin treatment for diabetic patients with low levels.
  • Lifestyle modification and other agents for diabetic patients with normal or elevated levels.
Clinical Significance