Explore this test

  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
DOWNLOAD SPECIMEN PREP FLYER

Explore this test

Test Code 408(Includes glucose and insulin)

Test Details

Insulin Resistance

The standard measure of insulin resistance is the homeostasis model, based on both fasting insulin and fasting glucose level. Also called Homeostasis Model of Insulin Resistance (HOMA-IR).

Methodology

Insulin Resistance is calculated as:
Homeostasis Model of Insulin Resistance (HOMA-IR) = [fasting insulin (uU/ml) X fasting glucose (mg/dl)] /401.85

Patient Preparation

Fasting is required

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

None

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated:  3 days

Lab Values

Lab Values

Insulin Resistance

  • Optimal:  <2.0
  • Borderline: 2.0 – 3.0
  • Increased Risk: >3.0
Test Details
Clinical Significance

Clinical Significance

Insulin Resistance

The presence of insulin resistance (value > 3.0) indicates a high risk of developing1:

  • Coronary heart disease
  • Stroke
  • Peripheral vascular disease
  • Type 2 diabetes mellitus
  • Hypertension
  • Hyperlipidemia

References:

  1. Haff ner S. Relationship of Metabolic Risk Factors and Development of Cardiovascular Disease and Diabetes. Obesity. 2006;14(Suppl 3):121S-127S.
Lab Values
Treatment Options

Treatment Options

Insulin Resistance

  • Lifestyle modification
  • Glucose stabilizing and/or insulin sensitizing medications
Clinical Significance