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Test Code 302

Test Details

Apolipoprotein B (apoB)

ApoB is a protein produced in the liver and intestine that provides structure to triglyceride (TG) carrying atherogenic lipoprotein particles. Each particle carries only one apoB protein. Thus, apoB is a direct measure of the number of atherogenic particles in the bloodstream. ApoB is also a surrogate marker for LDL particle concentration or LDL particle number since LDL comprises about 90% of the atherogenic lipoprotein particles.

  • Very low-density lipoproteins (VLDL)
  • Intermediate-density lipoproteins (IDL)
  • Low-density lipoproteins (LDL)
  • Lp(a)
  • Chylomicrons

Methodology

Immunoturbidimetric

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 8 days

Lab Values

Lab Values

Apolipoprotein B (apoB)

  • Optimal: <80 mg/dL
  • Borderline: 80–120 mg/dL
  • Increased Risk: >120 mg/dL
Test Details
Clinical Significance

Clinical Significance

Apolipoprotein B (apoB)

Elevated levels of apoB are significant predictors of heart disease and are a more significant indicator of CVD than LDL-C.1

References:

  1. Tsai MY, Steff en BT, Guan W, et al. New automated assay of small dense low-density lipoprotein cholesterol identifies risk of coronary heart disease: the Multi-ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(1):196-201.
Lab Values
Treatment Options

Treatment Options

Apolipoprotein B (apoB)

  • Lifestyle modification
  • Statins
  • Niacin
  • Fibrates
  • Cholesterol absorption inhibitors
  • Bile acid sequestrants
Clinical Significance