Test Code 301
Test Details
Apolipoprotein A-I (apoA-I)
ApoA-I is a protein produced in both the liver and intestine. It provides structure to HDL particles as well as activates enzymes that add a fatty acid to cholesterol (esterifies cholesterol) and allows it to enter the core of HDL.
Methodology
Immunoturbidimetric
Patient Preparation
None
Preferred Specimen
1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)
Alternate Specimen
1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 8 days
Lab Values
Apolipoprotein A-I (apoA-I)
Male
- Optimal: >160 mg/dL
- Borderline: 120–160 mg/dL
- Increased Risk: <120 mg/dL
Female
- Optimal: >180 mg/dL
- Borderline: 140–180 mg/dL
- Increased Risk: <140 mg/dL
Clinical Significance
Apolipoprotein A-I (apoA-I)
Low level is associated with higher CVD risk.1
References:
- Ai M, Otokozawa S, Asztalos BF, Ito Y, Nakajima K, White CC, Cupples LA, Wilson PW, Schaefer EJ. Small dense low density lipoprotein cholesterol and coronary heart disease: results from the Framingham Off spring Study. Clin Chem. 2010; 56(6):967-976.
Treatment Options
Apolipoprotein A-I (apoA-I)
- Lifestyle modification
- Niacin
- Statin
