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Test Code 301

Test Details

Apolipoprotein A-I (apoA-I)

ApoA-I is a protein produced in both the liver and intestine. It provides structure to HDL particles as well as activates enzymes that add a fatty acid to cholesterol (esterifies cholesterol) and allows it to enter the core of HDL.

Methodology

Immunoturbidimetric

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 8 days

Lab Values

Lab Values

Apolipoprotein A-I (apoA-I)

Male

  • Optimal: >160 mg/dL
  • Borderline: 120–160 mg/dL
  • Increased Risk: <120 mg/dL

Female

  • Optimal: >180 mg/dL
  • Borderline: 140–180 mg/dL
  • Increased Risk: <140 mg/dL
Test Details
Clinical Significance

Clinical Significance

Apolipoprotein A-I (apoA-I)

Low level is associated with higher CVD risk.1

References:

  1. Ai M, Otokozawa S, Asztalos BF, Ito Y, Nakajima K, White CC, Cupples LA, Wilson PW, Schaefer EJ. Small dense low density lipoprotein cholesterol and coronary heart disease: results from the Framingham Off spring Study. Clin Chem. 2010; 56(6):967-976.
Lab Values
Treatment Options

Treatment Options

Apolipoprotein A-I (apoA-I)

  • Lifestyle modification
  • Niacin
  • Statin
Clinical Significance