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Test Code 407

Test Details

Adiponectin

Adiponectin is a measure of the amount of a hormone produced by fat cells that protects against developing heart disease and diabetes.

Methodology

Latex Immunoturbidimetric

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)

Alternate Specimen

None

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated:  7 days

Lab Values

Lab Values

Adiponectin

Male

  • Optimal: >10.0 µg/mL
  • Borderline: 7.0-10.0 µg/mL
  • Increased Risk: <7.0 µg/mL

Female

  • Optimal: >13.0 µg/mL
  • Borderline: 9.0-13.0 µg/mL
  • Increased Risk: <9.0 µg/mL
Test Details
Clinical Significance

Clinical Significance

Adiponectin

Low values indicate increased risk of diabetes.1

References:

  1. Ai M, Otokozawa S, Asztalos BF, et al. Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham Off spring Study. Atherosclerosis. 2011;217(2):543-548.
  2. Woo YC, Tso AWK, Xu A, Law LSC, Fong CHY, Lam TH, Lo SV, Wat NMS, Cheung BWY, Lam KSL. Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was compared to 2-hour post load glucose in diabetes prediction. PLOS ONE 2012;7: e36868.
  3. Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, Hegele RA, Retnakaran R, Zinman B, Hanley AJG Adipokines and incident type 2 diabetes in an aboriginal Canadian population, Diabetes Care 2008;31:1410-1415.
  4. Raynor LA, Pankow JS, Duncan BB, Schmidt MUI, Hoogeveen RC, Pereira MA, Young JH, Ballantyne CB. Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 2013;36:70-76.
  5. Julia C, Czernichow S, Charnaux N, Ahluwalia N, Andreeva V, Touvier M, Galan P, Fezeu L, Relationship between adipokines, biomarkers of endothelial function and inflammation and risk of type 2 diabetes. Diabetes Research and Clinical Practice 2014;105:231-238.
  6. Vinithia R, Ram J, Snehallatha C, Nanditha A, Shetty AN, Arun R, Godsland IF, Johnston D, Ramachandran A. Adiponectin, leptin, interleukin-6, and HbA1c in the prediction of incident type 2 diabetes: a nested case control, study in Asian Indian men with impaired glucose tolerance. Diabetes Research and Clinical practice 2015;109:340-346.
  7. Savolainen O, Fagerberg B, Lind MV, Sandberg AS, Ross AB, Bergstroem G. Biomarkers for predicting type 2 diabetes development – Can metabolomics improve on existing biomarkers. Plos One 2017;12e0177738.
  8. Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: an exposure wide umbrella review of meta-analyses. PLOS ONE 2018;13:e0194127.
Lab Values
Treatment Options

Treatment Options

Adiponectin

  • Lifestyle modification
  • Niacin
  • Fibrates
  • Omega-3 Fatty Acids
Clinical Significance