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  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 407

Test Details

Adiponectin

Adiponectin is a measure of the amount of a hormone produced by fat cells that protects against developing heart disease and diabetes.

Methodology

Latex Immunoturbidimetric

Patient Preparation

None

Preferred Specimen

Red & Yellow Top Tube
(CAT serum separator clot activator with gel)

Alternate Specimen

None

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated:  7 days

Lab Values

Lab Values

Adiponectin

Male

  • Optimal: >10.0 µg/mL
  • Borderline: 7.0-10.0 µg/mL
  • Increased Risk: <7.0 µg/mL

Female

  • Optimal: >13.0 µg/mL
  • Borderline: 9.0-13.0 µg/mL
  • Increased Risk: <9.0 µg/mL
Test Details
Clinical Significance

Clinical Significance

Adiponectin

Low values indicate increased risk of diabetes.1

References:

  1. Ai M, Otokozawa S, Asztalos BF, et al. Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham Off spring Study. Atherosclerosis. 2011;217(2):543-548.
  2. Woo YC, Tso AWK, Xu A, Law LSC, Fong CHY, Lam TH, Lo SV, Wat NMS, Cheung BWY, Lam KSL. Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was compared to 2-hour post load glucose in diabetes prediction. PLOS ONE 2012;7: e36868.
  3. Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, Hegele RA, Retnakaran R, Zinman B, Hanley AJG Adipokines and incident type 2 diabetes in an aboriginal Canadian population, Diabetes Care 2008;31:1410-1415.
  4. Raynor LA, Pankow JS, Duncan BB, Schmidt MUI, Hoogeveen RC, Pereira MA, Young JH, Ballantyne CB. Novel risk factors and the prediction of type 2 diabetes in the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 2013;36:70-76.
  5. Julia C, Czernichow S, Charnaux N, Ahluwalia N, Andreeva V, Touvier M, Galan P, Fezeu L, Relationship between adipokines, biomarkers of endothelial function and inflammation and risk of type 2 diabetes. Diabetes Research and Clinical Practice 2014;105:231-238.
  6. Vinithia R, Ram J, Snehallatha C, Nanditha A, Shetty AN, Arun R, Godsland IF, Johnston D, Ramachandran A. Adiponectin, leptin, interleukin-6, and HbA1c in the prediction of incident type 2 diabetes: a nested case control, study in Asian Indian men with impaired glucose tolerance. Diabetes Research and Clinical practice 2015;109:340-346.
  7. Savolainen O, Fagerberg B, Lind MV, Sandberg AS, Ross AB, Bergstroem G. Biomarkers for predicting type 2 diabetes development – Can metabolomics improve on existing biomarkers. Plos One 2017;12e0177738.
  8. Bellou V, Belbasis L, Tzoulaki I, Evangelou E. Risk factors for type 2 diabetes mellitus: an exposure wide umbrella review of meta-analyses. PLOS ONE 2018;13:e0194127.
Lab Values
Treatment Options

Treatment Options

Adiponectin

  • Lifestyle modification
  • Niacin
  • Fibrates
  • Omega-3 Fatty Acids
Clinical Significance