Test Code 625
Test Details
Vitamin D, 25-OH
25-hydroxy vitamin D is a hormone precursor that promotes bone, calcium and phosphorus metabolism.
Methodology
Antibody-based chemiluminescence
Patient Preparation
None
Preferred Specimen
Green Top Tube
(Lithium Heparin plasma separator tube with gel)
Alternate Specimen
Dried Blood collected on an AdvanceDx 100 card
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 7 days
Lab Values
Vitamin D, 25-OH
- Low: <30 ng/mL
- Mid: 30–100 ng/mL
- High: >100 ng/mL
Clinical Significance
Vitamin D, 25-OH
Vitamin D insufficiency is associated with:1
- Secondary hyperparathyroidism
- Muscle weakness with increased fall risk
- Myalgias
Vitamin D insufficiency may be associated with:2-4
- Deleterious effects on cardiovascular system
- Impaired pancreatic function
- Increased mortality
References:
- Muscogiuri G, Sorcie GP, Ajjan R, et al. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis. 2012;22(2):81-7.
- Goodman N, Cobin RH. Reproductive disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:190-228.
- Castro MR, Gharib H. Thyroid disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:43-80.
- Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.
Treatment Options
Vitamin D, 25-OH
- Vitamin D, 25-OH – High levels indicated toxic levels of vitamin D. Consider discontinuing vitamin D supplements.
- Vitamin D, 25-OH – Low vitamin D supplements. Vitamin D supplements can increase low blood levels of vitamin D, which have been associated with an increased risk of CVD and diabetes. Vitamin D supplements are frequently taken together with calcium to help maintain bone and muscle strength.
