Test Code 257(includes VLDL-C and triglycerides)
Test Details
Very Low-Density Lipoprotein Cholesterol/Triglycerides Ratio (VLDL-C/TG)
This is a ratio calculated by dividing very low density lipoprotein cholesterol by triglycerides. A high ratio is linked to abnormal lipid metabolism and increased risk of CVD events.
Methodology
The VLDL-C ratio is calculated as follows:
VLDL-C/TG ratio = VLDL-C/TG
Patient Preparation
8-12 hour fast prior to collection. Patient may drink water only.
Preferred Specimen
Green Top Tube
(Lithium Heparin plasma separator tube with gel)
Alternate Specimen
None
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 7 days
Lab Values
Very Low-Density Lipoprotein Cholesterol/Triglycerides Ratio (VLDL-C/TG)
- Optimal: <0.20
- Borderline: 0.20 – 0.30
- Increased Risk: >0.30
Clinical Significance
Very Low-Density Lipoprotein Cholesterol/Triglycerides Ratio (VLDL-C/TG)
- When the VLDL-C/TG ratio is > 0.30 it indicates the presence of cholesterol-rich chylomicron and VLDL remnant lipoproteins, which increase CVD risk.1
- A VLDL-C/TG ratio of > 0.30 has been associated with an increased risk of CVD and dysbetalipoproteinemia often associated with the apoE2/2 genotype.
References:
- Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73.
Treatment Options
Very Low-Density Lipoprotein Cholesterol/Triglycerides Ratio (VLDL-C/TG)
- Lifestyle modification
- Statins
- Niacin
- Fibrates
- Cholesterol absorption inhibitors
