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Test Code 254(includes total cholesterol and HDL-C)

Test Details

Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)

This is a ratio calculated by dividing total cholesterol by HDL cholesterol.

Methodology

TC/HDL-C is calculated as follows:
TC/HDL-C = Total cholesterol/High-density cholesterol

Patient Preparation

8-12 hour fast prior to collection. Patient may drink water only.

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 7 days

Lab Values

Lab Values

Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)

Without CVD

  • Optimal: <4.0
  • Borderline: 4.0–6.0
  • Increased Risk: >6.0

With CVD or CVD Risk Equivalent

  • Optimal: <3.0
  • Borderline: 3.0–5.0
  • High Risk: >5.0
Test Details
Clinical Significance

Clinical Significance

Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)

The TC/HDL-C ratio has been shown in many studies to be a more significant CVD risk factor than either LDL-C or HDL-C alone, or in combination.1-3

References:

  1. Contois JH, McConnell JP, Sethi A A, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009;55(3):407–419.
  2. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73.
  3. Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73.

 

Lab Values
Treatment Options

Treatment Options

Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)

  • Lifestyle modification
  • Statins
  • Niacin
  • Fibrates
  • Cholesterol absorption inhibitors
  • Bile acid sequestrants
Clinical Significance