Test Code 254(includes total cholesterol and HDL-C)
Test Details
Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)
This is a ratio calculated by dividing total cholesterol by HDL cholesterol.
Methodology
TC/HDL-C is calculated as follows:
TC/HDL-C = Total cholesterol/High-density cholesterol
Patient Preparation
8-12 hour fast prior to collection. Patient may drink water only.
Preferred Specimen
Green Top Tube
(Lithium Heparin plasma separator tube with gel)
Alternate Specimen
None
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 7 days
Lab Values
Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)
Without CVD
- Optimal: <4.0
- Borderline: 4.0–6.0
- Increased Risk: >6.0
With CVD or CVD Risk Equivalent
- Optimal: <3.0
- Borderline: 3.0–5.0
- High Risk: >5.0
Clinical Significance
Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)
The TC/HDL-C ratio has been shown in many studies to be a more significant CVD risk factor than either LDL-C or HDL-C alone, or in combination.1-3
References:
- Contois JH, McConnell JP, Sethi A A, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009;55(3):407–419.
- Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73.
- Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73.
Treatment Options
Total Cholesterol/High-Density Lipoprotein Cholesterol (TC/HDL-C)
- Lifestyle modification
- Statins
- Niacin
- Fibrates
- Cholesterol absorption inhibitors
- Bile acid sequestrants
