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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 1185

Test Details

Thyroglobulin Antibody (Anti-Tg)

An antibody directed against the thyroid-specific protein thyroglobulin (Tg). Increased antibody levels are often associated with thyroiditis including Hashimotos, Graves, and post-partum thyroditis.

Methodology

Chemiluminescence

Patient Preparation

Preferred Specimen

Green Top Tube
(Lithium Heparin plasma separator tube with gel)

Alternate Specimen

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 7 days

Lab Values

Lab Values

Thyroglobulin Antibody (Anti-Tg)

  • Optimal: ≤60 IU/mL
  • Increased Risk: >60 IU/mL
Test Details
Clinical Significance

Clinical Significance

Thyroglobulin Antibody (Anti-Tg)

Tg antibodies are mainly used to evaluate a diagnostic suspicion of autoimmune thyroiditis, and are usually requested together with TPO antibodies. Tg antibodies are polyclonal antibodies to Tg with a prevalence of 20%–90% in Hashimoto thyroiditis and 30%–60% in Graves disease, but, like TPO Abs, they are also present in 10%–27% of healthy adults. Tg antibodies are less common and of lower titer than TPO antibodies. The majority of patients with Hashimoto’s thyroiditis have TPO and/or Tg antibodies, such that a negative antibody result has a high negative predictive value. The titer of Tg antibodies does not usually correlate with the degree of thyroid dysfunction.

References:

  1. Burek CL, Rose NR, Caturegli P. Thyroglobulin, thyroperoxidase, and thyrotropin-receptor autoantibodies. In Autoantibodies (second edition), 2007. Science Direct: https://doi.org/10.1016/B978-044452763-9/50055-X
Lab Values
Treatment Options

Treatment Options

Thyroglobulin Antibody (Anti-Tg)

Treatment is based on etiology of elevation and clinical symptoms.

Clinical Significance