Explore this test

Test Code 223

Test Details

Small Dense LDL Cholesterol (sdLDL-C)

Small dense LDL particles are denser and more atherogenic LDL-particles. sdLDL-C gives the total amount of LDL-C in the small dense format.

Methodology

Enzymatic

Patient Preparation

Morning draw and fasting preferred.

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 3 days

Lab Values

Lab Values

Small Dense LDL Cholesterol (sdLDL-C)

  • Optimal: <20 mg/dL
  • Borderline: 20–40 mg/dL
  • Increased Risk: >40 mg/dL
Test Details
Clinical Significance

Clinical Significance

Small Dense LDL Cholesterol (sdLDL-C)

High levels are associated with a two- to three-fold increased risk for CVD events.1-3

References:

  1. Ai M, Otokozawa S, Asztalos BF, Ito Y, Nakajima K, White CC, Cupples LA, Wilson PW, Schaefer EJ. Small dense low density lipoprotein cholesterol and coronary heart disease: results from the Framingham Off spring Study. Clin Chem. 2010; 56(6):967-976.
  2. Tsai MY, Steff en BT, Guan W, et al. New automated assay of small dense low-density lipoprotein cholesterol identifies risk of coronary heart disease: the Multi-ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(1):196-201.
  3. Hirano T, Ito Y, Koba S, et al. Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method. Arterioscler Thromb Vasc Biol. 2004;24(3):558–563.
Lab Values
Treatment Options

Treatment Options

Small Dense LDL Cholesterol (sdLDL-C)

  • Lifestyle modification
  • Statins
  • Niacin
  • Fibrates
  • Omega-3 Fatty Acids
Clinical Significance