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PSA is secreted by epithelial cells of the prostate gland and is present in small quantities in the serum of men with healthy prostate glands. Total serum PSA assay is an excellent adjunct to a rectal examination for the diagnosis of prostate cancer, as well as for follow-up of patients with diagnosed prostate cancer.
Recommend waiting at least 24 hours after a rectal exam before testing PSA
1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)
Refrigerated (ship on frozen cold packs)
Refrigerated: 5 days
- Optimal: < 4.0 ng/mL
- High: > 4.0 ng/mL
Increased levels are associated with an increased risk of prostate cancer, but may also be seen in subjects with benign prostatic hypertrophy.
This test is performed using the Roche Diagnostics chemiluminescent method. Values obtained from different assay methods cannot be used interchangeably. PSA levels, regardless of value, should not be interpreted as absolute evidence of the presence or absence of disease.
- High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.
PSA levels can be used to monitor for prostate cancer in men receiving testosterone replacement.