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  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 816

Test Details

Factor V Leiden Genotype Test

Factor V is a coagulation protein produced by the liver. The factor V Leiden genotype is a variant form of factor V with a change in one of the amino acids resulting in increased clot formation. The intended use of Factor V Leiden testing is as an aid in selection of appropriate thrombosis prevention regimens. The genetic test identifies individuals with defects in clotting factors, thus allowing the physician to determine the need for more aggressive thrombosis prevention measures for these individuals. Such therapy prevents life-threatening clots, especially those that travel from veins in the legs to the lungs (pulmonary emboli).

Methodology

Real time polymerase chain reaction (PCR)

Patient Preparation

None

Preferred Specimen

1.0 mL whole blood collected in EDTA (Lavender Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 15 days

Lab Values

Lab Values

Factor V Leiden Genotype Test

Genotypes -/-, +/-, +/+

Test Details
Clinical Significance

Clinical Significance

Factor V Leiden Genotype Test

Genotype -/-
normal risk of clot formation

Genotypes +/-
increased risk of developing clots, especially if on oral estrogen therapy

Genotype +/+
markedly increased risk of developing clots, especially if on oral estrogen therapy

Lab Values
Treatment Options

Treatment Options

Factor V Leiden Genotype Test

Genotypes +/-, +/+
consider low dose aspirin treatment

Clinical Significance