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  • Lab Values
  • Clinical Significance
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Test Code 826

Test Details

Prothrombin (Factor II) G20210A Genotype Test

Factor II (prothrombin) is a coagulation protein produced by the liver. The factor II genotype is a variant form of factor II with a change in one of the amino acids resulting in increased clot formation.1 The intended use for Prothrombin (Factor II) testing is as an aid in selection of appropriate thrombosis prevention regimens. The genetic test identifies individuals with defects in clotting factors, thus allowing the physician to determine the need for more aggressive thrombosis prevention measures for these individuals. Such therapy prevents life-threatening clots, especially those that travel from veins in the legs to the lungs (pulmonary emboli).

References:

  1. DeStefano V, Rossi E. Testing for inherited thrombophilia and consequences for antithrombotic prophylaxis in patients with venous thromboembolism and their relatives. Thromb Haemost. 2013 Oct;110(4):697-705.

Methodology

Real time polymerase chain reaction (PCR)

Patient Preparation

None

Preferred Specimen

1.0 mL whole blood collected in EDTA (Lavender Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 15 days

Lab Values

Lab Values

Prothrombin (Factor II) G20210A Genotype Test

Genotypes -/-, +/-, +/+

Test Details
Clinical Significance

Clinical Significance

Prothrombin (Factor II) G20210A Genotype Test

Genotype -/-

normal risk of clot formation

Genotypes +/-

increased risk of developing clots, especially if on oral estrogen therapy

Genotype +/+

markedly increased risk of developing clots, especially if on oral estrogen therapy

Lab Values
Treatment Options

Treatment Options

Prothrombin (Factor II) G20210A Genotype Test

Genotypes +/-, +/+:  consider low dose aspirin treatment

Clinical Significance