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- Test Details
- Lab Values
- Clinical Significance
- Treatment Options
MPO is an enzyme found in circulating white blood cells (neutrophils) and is also produced by white blood cells (monocytes) in the foam cells within the artery wall. Elevated levels of MPO may indicate the presence of unstable plaque or buildup in the arterial wall and an increased risk of plaque rupture. In patients with high levels of MPO, careful evaluation of CVD risk should be considered by the healthcare professional.
1.0 mL EDTA plasma collected in plasma separator tube (Pearl Top)
Refrigerated (ship on frozen cold packs)
Refrigerated: 4 days
- Optimal: <470 pmol/L
- Borderline: 470-539 pmol/L
- Increased Risk: ≥540 pmol/L
- Alert: >1658 pmol/L
- Elevated MPO levels have been shown to be a significant independent risk factor for a major adverse cardiac event (MACE) over the ensuing one to six months.1
- Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349(17):1595-1604.
- Evaluate cardiovascular disease (CVD) status with physical exam, stress testing and other CVD diagnostic modalities.
- Modify all existing CVD risk factors.
- Medications to reduce elevated MPO levels may include:
- Angiotensin enzyme converting inhibitors