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Lp(a) is a plasma lipoprotein that is composed of two parts:
- LDL-like particle
- Apolipoprotein (a) [apo(a)], a protein made in the liver and attached to the apoB portion of this particle
Levels are determined by genetic factors.
1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)
1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)
Refrigerated (ship on frozen cold packs)
Refrigerated: 7 days
- Optimal: <30 mg/dL
- Borderline: 30–50 mg/dL
- High Risk: >50 mg/dL
Elevated levels are an independent risk factor for CVD.1-3
- Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J. 2010;31(23):2844–2853.
- Hoff HF, Beck GJ, Skibinski CI, et al. Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients. Circulation. 1988;77(6):1238–1244.
- Lamon-Fava S, Marcovina SM, Albers JJ, Kennedy H, Deluca C, White CC, Cupples LA, McNamara JR, Seman LJ, Bongard V, Schaefer EJ. Lipoprotein(a) levels, isoforms, and coronary heart disease risk in the Framingham Off spring Study. J Lipid Res. 2011;52(6):1181-1187.
- Optimize LDL-C, sdLDL-C and apoB