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Test Code 98006

Test Details

LDL Particle Number (LDL-P)

LDL-P is a measurement of the number of LDL particles in serum as opposed to LDL-C which is the measurement of the amount of cholesterol inside the LDL particle.

Methodology

600 MHz nuclear magnetic resonance (NMR)

Patient Preparation

8-12 hour fast prior to collection. Patient may drink water, black coffee or tea (no milk, cream or sugar).

Preferred Specimen

2.0 mL serum (1.0 mL minimum) collected in red/yellow top serum separator tube (Z-Top tube)

Alternate Specimen

2.0 mL serum (1.0 mL minimum) collected in black/yellow top serum separator tube (Z-Top tube)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 12 days

Lab Values

Lab Values

LDL Particle Number (LDL-P)

  • Optimal: <1200 nmol/L
  • Borderline: 1200-1800 nmol/L
  • Increased Risk: >1800 nmol/L
Test Details
Clinical Significance

Clinical Significance

LDL Particle Number (LDL-P)

An alternative measure of LDL quantity is LDL particle number (LDL-P), determined directly by nuclear magnetic resonance (NMR) spectroscopy. Data from multiple epidemiological studies have demonstrated that LDL-P better predicts cardiovascular events than LDL-C concentrations, particularly in patients whose LDL-P and LDL-C levels are discordant.1

References:

  1. Cole TG, Contois JH, Csako G, et al. Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL particle number with outcomes in 25 clinical studies: assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2013;59(5):752-770.
Lab Values
Treatment Options

Treatment Options

LDL Particle Number (LDL-P)

  • Lifestyle Modification
  • Statins
  • Niacin
  • Fibrates
  • Cholesterol absorption inhibitors (ezetimibe)
  • Bile acid sequestrants
Clinical Significance