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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 601

Test Details

High Sensitivity C-Reactive Protein (hs-CRP)

CRP is an acute phase inflammatory plasma protein synthesized by the liver. The “high sensitivity” CRP test is needed to detect very low levels of CRP that may be seen with vascular and/or systemic inflammation.

Methodology

Immunoturbidimetric

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 2 months

Lab Values

Lab Values

High Sensitivity C-Reactive Protein (hs-CRP)

  • Optimal: <1.0 mg/L
  • Borderline: 1.0–3.0 mg/L
  • Increased Risk: >3.0 mg/L
Test Details
Clinical Significance

Clinical Significance

High Sensitivity C-Reactive Protein (hs-CRP)

  • hs-CRP may be an independent predictor of developing CVD events and can provide independent prognostic information after initiating treatment.
  • High levels of hs-CRP can also predict cardiovascular events and may be useful in determining how well a patient is responding to lifestyle change and statin treatment.1

References:

  1. Ridker PM, Danielson E, Fonseca FA, et al. JUPITER Trial Study Group. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet. 2009;373(9670):1175-1182.
Lab Values
Treatment Options

Treatment Options

High Sensitivity C-Reactive Protein (hs-CRP)

  • Lifestyle modification
  • Statins
  • Niacin
  • Fibrates
  • Omega-3 Fatty Acids
Clinical Significance