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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 610

Test Details

Folate

Folate is necessary for normal metabolism, DNA synthesis and red blood cell regeneration. Untreated deficiencies may lead to megaloblastic anemia. One of the most important folate-dependent reactions is the conversion of homocysteine to methionine.

Methodology

Electrochemiluminescence Immunoassay (ECLIA)

Patient Preparation

8 hour fast prior to collection. Patient may drink water, black coffee, or tea (no milk, cream or sugar).

Preferred Specimen

1.0 mL serum collected in a serum separator tube (SST / Tiger Top)

Transport Temperature

Refrigerate immediately (ship on frozen cold packs)

Stability

Refrigerated: 2 days

Lab Values

Lab Values

Folate

  • Increased Risk: <12.0 ng/mL
  • Borderline: 12.0-18.0 ng/mL
  • Optimal: >18.0 ng/mL
Test Details
Clinical Significance

Clinical Significance

Folate

Isolated folate deficiency is uncommon; it usually coexists with other nutrient deficiencies because of its strong association with poor diet, alcoholism, and, sometimes, malabsorptive disorders. Women with insufficient folate intakes are at increased risk of giving birth to infants with neural tube defects.

  • High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.
  • Lab Values
    Treatment Options

    Treatment Options

    Folate

    Treatment is based on the cause of the folate deficiency. Folate supplementation may be necessary. Individuals with MTHFR 677T genotype may require supplementation with methyl folate instead of folate to adequately lower their homocysteine levels.

    Clinical Significance