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- Test Details
- Lab Values
- Clinical Significance
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Fibrinogen or Factor I is an acute phase inflammatory plasma protein synthesized by the liver and is an essential component in the clotting cascade.
0.5 mL EDTA plasma collected in plasma separator tube (Pearl Top)
Refrigerated (ship on frozen cold packs)
Refrigerated: 2 days
- Optimal: <370 mg/dL
- Borderline: 370-470 mg/dL
- Increased Risk: >470 mg/dL
- Fibrinogen is converted by thrombin to form fibrin, which is crosslinked with another protein in the final step in the formation of a blood clot.
- Elevated levels are associated with inflammation.
- Every 100 mg/dL increase in plasma fibrinogen level > 370 mg/dL has been associated with a 1.8 fold increased risk of CVD.1
- Fibrinogen Studies Collaboration. Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799-1809.
- Lifestyle modification