Test Code 701
Test Details
Fibrinogen
Fibrinogen or Factor I is an acute phase inflammatory plasma protein synthesized by the liver and is an essential component in the clotting cascade.
Methodology
Immunoturbidimetric
Patient Preparation
None
Preferred Specimen
0.5 mL EDTA plasma collected in plasma separator tube (Pearl Top)
Alternate Specimen
None
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 2 days
Lab Values
Fibrinogen
- Optimal: <370 mg/dL
- Borderline: 370-470 mg/dL
- Increased Risk: >470 mg/dL
Clinical Significance
Fibrinogen
- Fibrinogen is converted by thrombin to form fibrin, which is crosslinked with another protein in the final step in the formation of a blood clot.
- Elevated levels are associated with inflammation.
- Every 100 mg/dL increase in plasma fibrinogen level > 370 mg/dL has been associated with a 1.8 fold increased risk of CVD.1
References:
- Fibrinogen Studies Collaboration. Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799-1809.
Treatment Options
Fibrinogen
- Lifestyle modification
