Test Code 1128
Test Details
Estradiol (Estrogen Fraction E2)
Estradiol is the most potent naturally occurring estrogen. Estrogens are the female hormones produced by the ovaries, adrenal cortex, placenta, and testes. Estrogens prepare the uterus for implantation of the fertilized ovum and promote the maturation of and maintenance of female secondary sex characteristics and reproductive organs.
Methodology
Immunoassay-Competitive principle
Patient Preparation
None
Preferred Specimen
1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)
Alternate Specimen
None
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 2 days
Lab Values
Estradiol (Estrogen Fraction E2)
Men:
| Sex/Phase | Optimal |
| N/A | 11.3 – 43.2 pg/mL |
Women:
| Sex/Phase | Optimal |
| Follicular phase | 12.4 – 233.0 pg/mL |
| Ovulation phase | 41.0 – 398.0 pg/mL |
| Luteal phase | 22.3 – 341.0 pg/mL |
| Postmenopause | <138.0 pg/mL |
Clinical Significance
Estradiol (Estrogen Fraction E2)
- Estradiol is used in the assessment of menopausal status, fertility disorders in the hypothalamus-pituitary-gonad axis, gynecomastia, estrogen-producing ovarian and testicular tumors and in hyperplasia of the adrenal cortex
- Is also used for monitoring of fertility therapy and determining the time of ovulation within the framework of in vitro fertilization.
- High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.
Treatment Options
Estradiol (Estrogen Fraction E2)
- Identify etiology of elevated or decreased estradiol levels with physical assessment and additional diagnostic tests as indicated
- Treatment is based on etiology of abnormal hormone level
