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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Explore this test

Test Code N/Aautomatically calculated when serum creatinine is ordered

Test Details

Estimated Glomerular Filtration Rate (eGFR) / Creatinine

Glomerular filtration rate (GFR) provides a measure of kidney filtering capacity. Total GFR can be used as an index of functioning renal mass. Estimated GFR (eGFR)/Creatinine is calculated based on serum creatinine, age, gender and ethnic background.

Methodology

Serum creatinine (Scr) and age are used to calculate eGFR, taking sex and race into account. The specific equation used is:

GFR = 141 x min(Scr/κ, 1)α x max(Scr/κ, 1)-1.209 x 0.993Age x 1.018 [if female] x 1.159 [if African American]

κ = 0.7 if female
κ = 0.9 if male

α = -0.329 if female
α = -0.411 if male

min = The minimum of Scr/κ or 1
max = The maximum of Scr/κ or 1

Patient Preparation

None

Preferred Specimen

N/A

Alternate Specimen

N/A

Transport Temperature

N/A

Stability

N/A

Lab Values

Lab Values

Estimated Glomerular Filtration Rate (eGFR) / Creatinine

  • Optimal: >60 mL/min/1.73 m2
  • Borderline: 30-60 mL/min/1.73 m2
  • Increased Risk:  <30 mL/min/1.73 m2
Test Details
Clinical Significance

Clinical Significance

Estimated Glomerular Filtration Rate (eGFR) / Creatinine

  • A low or decreasing eGFR is an indicator of chronic kidney disease (CKD).1
  • Monitoring changes in eGFR help in monitoring kidney function and can delineate progression of kidney disease.1
  • The level of GFR is a strong predictor of the time to onset of kidney failure as well as the risk of complications of CKD.1
  • Monitoring eGFR allows proper dosing of drugs excreted by glomerular filtration to avoid drug toxicity.1

References:

  1. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification Kidney Disease Outcomes Quality Initiative. Am J Kidney Dis. 2002;39(Suppl 1):S1-266.
Lab Values
Treatment Options

Treatment Options

Estimated Glomerular Filtration Rate (eGFR) / Creatinine

Treatment is based on the cause of the renal dysfunction.1

References:

  1. National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification Kidney Disease Outcomes Quality Initiative. Am J Kidney Dis. 2002;39(Suppl 1):S1-266.
Clinical Significance