Test Code N/Aautomatically calculated when serum creatinine is ordered
Test Details
Estimated Glomerular Filtration Rate (eGFR) / Creatinine
Glomerular filtration rate (GFR) provides a measure of kidney filtering capacity. Total GFR can be used as an index of functioning renal mass. Estimated GFR (eGFR)/Creatinine is calculated based on serum creatinine, age, and gender.
Methodology
Serum creatinine and age are used to calculate eGFR, taking gender into account. The specific equation used is:
eGFR = 142 x min(Scr/κ, 1)α x max(Scr/κ, 1)-1.200 x 0.9938Age x 1.012 [if female]
Scr = serum creatinine in mg/dL
κ = 0.7 if female
κ = 0.9 if male
α = -0.241 if female
α = -0.302 if male
min = The minimum of Scr/κ or 1.0
max = The maximum of Scr/κ or 1.0
Age in years
Patient Preparation
None
Preferred Specimen
N/A
Alternate Specimen
N/A
Transport Temperature
N/A
Stability
N/A
Lab Values
Estimated Glomerular Filtration Rate (eGFR) / Creatinine
- Optimal: >60 mL/min/1.73 m2
- Borderline: 30-60 mL/min/1.73 m2
- Increased Risk: <30 mL/min/1.73 m2
Clinical Significance
Estimated Glomerular Filtration Rate (eGFR) / Creatinine
- A low or decreasing eGFR is an indicator of chronic kidney disease (CKD).1
- Monitoring changes in eGFR help in monitoring kidney function and can delineate progression of kidney disease.1
- The level of GFR is a strong predictor of the time to onset of kidney failure as well as the risk of complications of CKD.1
- Monitoring eGFR allows proper dosing of drugs excreted by glomerular filtration to avoid drug toxicity.1
References:
- National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification Kidney Disease Outcomes Quality Initiative. Am J Kidney Dis. 2002;39(Suppl 1):S1-266.
Treatment Options
Estimated Glomerular Filtration Rate (eGFR) / Creatinine
Treatment is based on the cause of the renal dysfunction.1
References:
- National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification Kidney Disease Outcomes Quality Initiative. Am J Kidney Dis. 2002;39(Suppl 1):S1-266.
