Explore this test

Test Code 303(includes Apolipoprotein B and Apolipoprotein A-I)

Test Details

Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)

The ratio of apolipoprotein B/apolipoprotein A-I is a strong predictor of heart disease risk. One molecule of apoB is carried per chylomicron, VLDL, LDL, and/or Lp(a) particle. ApoA-I is the major protein of HDL particles.

Methodology

ApoB/ApoA-I is  calculated as follows:
ApoB/ApoA-I Ratio = ApoB/ApoA-I

Patient Preparation

8-12 hour fast prior to collection.  Patient may drink water only.

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 7 days

Lab Values

Lab Values

Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)

Without CVD

  • Optimal: <0.6
  • Borderline: 0.6 – 0.9
  • Increased Risk: >0.90

With CVD

  • Optimal: <0.5
  • Borderline: 0.5 – 0.7
  • Increased Risk: >0.7
Test Details
Clinical Significance

Clinical Significance

Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)

The apoB/apoA-I ratio has been shown in many studies to be a more significant CVD risk factor than either LDL-C or HDL-C alone, or in combination.

Lab Values
Treatment Options

Treatment Options

Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)

  • Lifestyle modification
  • Statins
  • Cholesterol absorption inhibitor
  • Bile acid sequestrants
  • Fibrates
  • Niacin
Clinical Significance