Test Code 303(includes Apolipoprotein B and Apolipoprotein A-I)
Test Details
Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)
The ratio of apolipoprotein B/apolipoprotein A-I is a strong predictor of heart disease risk. One molecule of apoB is carried per chylomicron, VLDL, LDL, and/or Lp(a) particle. ApoA-I is the major protein of HDL particles.
Methodology
ApoB/ApoA-I is calculated as follows:
ApoB/ApoA-I Ratio = ApoB/ApoA-I
Patient Preparation
8-12 hour fast prior to collection. Patient may drink water only.
Preferred Specimen
Green Top Tube
(Lithium Heparin plasma separator tube with gel)
Alternate Specimen
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 7 days
Lab Values
Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)
Without CVD
- Optimal: <0.6
- Borderline: 0.6 – 0.9
- Increased Risk: >0.90
With CVD
- Optimal: <0.5
- Borderline: 0.5 – 0.7
- Increased Risk: >0.7
Clinical Significance
Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)
The apoB/apoA-I ratio has been shown in many studies to be a more significant CVD risk factor than either LDL-C or HDL-C alone, or in combination.
Treatment Options
Apolipoprotein B/Apolipoprotein A-I Ratio (ApoB/ApoA-I)
- Lifestyle modification
- Statins
- Cholesterol absorption inhibitor
- Bile acid sequestrants
- Fibrates
- Niacin
