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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 885

Test Details

9p21 CVD Risk Genotype Test

This test identifies individuals who may be at an increased risk of premature CVD which allows for risk reclassification and more aggressive management of modifiable risk factors.

The 9p21 gene locus is on chromosome 9. Two 9p21 variants rs10757278 and rs1333049, found in about 40% of the population, have about a 1.5-2.0 fold increased risk of cardiovascular disease versus non-carriers in population studies.

Reference:

  1. McPherson R, Pertsemilidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-1491.

Methodology

Real time polymerase chain reaction (PCR)

Patient Preparation

None

Preferred Specimen

1.0 mL whole blood collected in EDTA (Lavender Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 14 days

Lab Values

Lab Values

9p21 CVD Risk Genotype Test

rs10757278

  • Optimal
    • Genotype A/A
  • Borderline
    • Genotype A/G
  • High Risk
    • Genotype G/G

rs1333049

  • Optimal
    • Genotype G/G
  • Borderline
    • Genotype C/G
  • High Risk
    • Genotype C/C
Test Details
Clinical Significance

Clinical Significance

9p21 CVD Risk Genotype Test

rs10757278

  • Normal CVD Risk
    • Genotype A/A
  • 1.5-Fold Increased CVD Risk
    • Genotype A/G
  • 2.0-Fold Increased CVD Risk
    • Genotype G/G

rs1333049

  • Normal CVD Risk
    • Genotype G/G
  • 1.5-Fold Increased CVD Risk
    • Genotype C/G
  • 2.0-Fold Increased CVD Risk
    • Genotype C/C
Lab Values
Treatment Options

Treatment Options

9p21 CVD Risk Genotype Test

rs10757278

  • Optimize All CVD Risk Factors
    • Genotype A/G
    • Genotype G/G

rs1333049

  • Optimize All CVD Risk Factors
    • Genotype C/G
    • Genotype C/C
Clinical Significance