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Test Code 253

Test Details

% Small Dense LDL Cholesterol (%sdLDL)

This is a calculated value which indicates the percentage of total LDL-C due to sdLDL-C.

Methodology

% sdLDL-C is calculated as follows:
%sdLDL-C = (sdLDL-C/LDL-C ) X 100

Patient Preparation

8-12 hour fast prior to collection. Patient may drink water only.

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Alternate Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 3 days

Lab Values

Lab Values

% Small Dense LDL Cholesterol (%sdLDL)

  • Optimal: <20%
  • Borderline: 20–30%
  • Increased Risk: >30%
Test Details
Clinical Significance

Clinical Significance

% Small Dense LDL Cholesterol (%sdLDL)

A high percentage of LDL as small dense LDL has been associated with an increased risk for CVD events and rate of progression of coronary disease.1

References:

  1. Hirano T, Ito Y, Koba S, et al. Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method. Arterioscler Thromb Vasc Biol. 2004;24(3):558–563.
Lab Values
Treatment Options

Treatment Options

% Small Dense LDL Cholesterol (%sdLDL)

  • Lifestyle modification
  • Statins
  • Niacin
  • Fibrates
  • Omega-3 Fatty Acids
Clinical Significance