Test Code 253
Test Details
% Small Dense LDL Cholesterol (%sdLDL)
This is a calculated value which indicates the percentage of total LDL-C due to sdLDL-C.
Methodology
% sdLDL-C is calculated as follows:
%sdLDL-C = (sdLDL-C/LDL-C ) X 100
Patient Preparation
8-12 hour fast prior to collection. Patient may drink water only.
Preferred Specimen
1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)
Alternate Specimen
- 1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)
- Dried Blood collected on an AdvanceDx 100 card
Transport Temperature
Refrigerated (ship on frozen cold packs)
Stability
Refrigerated: 3 days
Lab Values
% Small Dense LDL Cholesterol (%sdLDL)
- Optimal: <20%
- Borderline: 20–30%
- Increased Risk: >30%
Clinical Significance
% Small Dense LDL Cholesterol (%sdLDL)
A high percentage of LDL as small dense LDL has been associated with an increased risk for CVD events and rate of progression of coronary disease.1
References:
- Hirano T, Ito Y, Koba S, et al. Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method. Arterioscler Thromb Vasc Biol. 2004;24(3):558–563.
Treatment Options
% Small Dense LDL Cholesterol (%sdLDL)
- Lifestyle modification
- Statins
- Niacin
- Fibrates
- Omega-3 Fatty Acids
