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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code DBS1075

Test Details

Anti-Mullerian Hormone (AMH)

Anti-Mullerian hormone (AMH) is a product of follicular cells in the ovaries of women of child-bearing age. As such, AMH is only present in the ovary until menopause. The assay is intended to assess ovarian reserve in women of child-bearing age.

Methodology

Chemiluminescent Immunoassay

Patient Preparation

None

Preferred Specimen

Dried Blood collected on an AdvanceDx 100 card

Alternate Specimen

None

Transport Temperature

Room temperature

Stability

14 days at room temperature

Lab Values

Lab Values

Anti-Mullerian Hormone (AMH)

Females

Optimal Values

Age ng/mL
0 – 17 Not established
18 – 25 1.02 -14.63
26 – 30 0.69-13.39
31 – 35 0.36-10.07
36 – 40 0.18-5.68
41 – 45 0.08-2.99
>45 Not established
Test Details
Clinical Significance

Clinical Significance

Anti-Mullerian Hormone (AMH)

Median values in women decline with age from about 4.0 ng/ml to about 0.50 ng/mL between age groups 26-30 years and 40-45 years. AMH is undetectable (<0.08 ng/mL) in post-menopausal women.

In one study which assessed ovarian follicle or egg count based on ultrasound analysis, 91.5% women with AMH values of ≤1.77 ng/mL had follicle count of ≤15 (low or normal ovarian reserve) and 8.5% had a follicle count of >15 (high ovarian reserve). In contrast, 51.6% of women with AMH values of >1.77 ng/mL, had a follicle count of >15, and 48.4% had a follicle count of ≤15. Therefore the AMH assay serves as a measure of ovarian reserve and follicle count as well as menopausal status.

References:

  1. Beckman ACCESS Anti-Muellerian Hormone Package Insert Reference B13127.
  2. Ledger WL. Clinical utility of measurement of anti-müllerian hormone in reproductive endocrinology. J Clin Endocrinol Metab. 2010;95::5144-54.
  3. 3. Fiçicioglu C, Kutlu T, Baglam E, Bakacak Z. Early follicular antimüllerian hormone as an indicator of ovarian reserve. Fertil Steril.2006;85:592-6.
  4. 4. Freeman EW, Sammel MD, Lin H, Boorman DW, Gracia CR. Contribution of the rate of change of antimüllerian hormone in estimating time to menopause for late reproductive-age women. Fertil Steril. 2012; 98:1254-9.
Lab Values
Treatment Options

Treatment Options

Anti-Mullerian Hormone (AMH)

Clinicians may consider consultation with a fertility specialist or a reproductive endocrinologist if clinically indicated.

Clinical Significance