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  • Test Details
  • Lab Values
  • Clinical Significance
  • Treatment Options
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Test Code 1075

Test Details

Anti-Mullerian Hormone (AMH)

Anti-Mullerian hormone (AMH) is a product of follicular cells in the ovaries of women of child-bearing age. As such, AMH is only present in the ovary until menopause. The assay is intended to assess ovarian reserve in women of child-bearing age.

Methodology

Chemiluminescent Immunoassay

Patient Preparation

None

Preferred Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST / Tiger Top)

Alternate Specimen

Dried Blood collected on an AdvanceDx 100 card

Transport Temperature

Room temperature

Stability

14 days at room temperature

Lab Values

Lab Values

Anti-Mullerian Hormone (AMH)

Females

Optimal Values

Age ng/mL
<20 Not established
20 – 24 1.52 – 9.95
25 – 29 1.20 – 9.05
30 – 34 0.71 – 7.59
35 – 39 0.41 – 6.96
40 – 44 0.06 – 4.44
>44 Not established
Test Details
Clinical Significance

Clinical Significance

Anti-Mullerian Hormone (AMH)

Median values in women decline with age from about 4.0 ng/ml to about 0.50 ng/mL between age groups 26-30 years and 40-45 years. AMH is undetectable (<0.08 ng/mL) in post-menopausal women.

In one study which assessed ovarian follicle or egg count based on ultrasound analysis, 91.5% women with AMH values of ≤1.77 ng/mL had follicle count of ≤15 (low or normal ovarian reserve) and 8.5% had a follicle count of >15 (high ovarian reserve). In contrast, 51.6% of women with AMH values of >1.77 ng/mL, had a follicle count of >15, and 48.4% had a follicle count of ≤15. Therefore the AMH assay serves as a measure of ovarian reserve and follicle count as well as menopausal status.

References:

  1. Beckman ACCESS Anti-Muellerian Hormone Package Insert Reference B13127.
  2. Ledger WL. Clinical utility of measurement of anti-müllerian hormone in reproductive endocrinology. J Clin Endocrinol Metab. 2010;95::5144-54.
  3. 3. Fiçicioglu C, Kutlu T, Baglam E, Bakacak Z. Early follicular antimüllerian hormone as an indicator of ovarian reserve. Fertil Steril.2006;85:592-6.
  4. 4. Freeman EW, Sammel MD, Lin H, Boorman DW, Gracia CR. Contribution of the rate of change of antimüllerian hormone in estimating time to menopause for late reproductive-age women. Fertil Steril. 2012; 98:1254-9.
Lab Values
Treatment Options

Treatment Options

Anti-Mullerian Hormone (AMH)

Clinicians may consider consultation with a fertility specialist or a reproductive endocrinologist if clinically indicated.

Clinical Significance